AI PROTEIN DESIGNER: Artificial Intelligence Creates Enzymes That Destroy Stable Bonds...

Researchers leveraged AI protein design to create custom enzymes that break down peptide bonds—the molecular links holding proteins together—which normally remain stable for centuries. By grafting the catalytic cores of two natural protease types onto entirely redesigned protein scaffolds, they produced enzymes tuned to target specific proteins with precision. The team demonstrated the approach by engineering proteases to degrade proteins linked to neurological diseases, sidestepping evolution's usual millions-of-years process to arrive at highly specialized protein-cutting tools in months.